Gonadal development in Tl6H/XSxr hermaphrodite mice
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چکیده
منابع مشابه
P450scc-like immunoreactivity throughout gonadal restructuring in the protogynous hermaphrodite Thalassoma duperrey.
The source of steroid hormones, which potentially regulate gonadal restructuring throughout protogynous sex change in teleosts, remains largely unknown. To address this issue, immunocytochemical methods were employed to detect gonadal sites of steroidogenesis in the protogynous hermaphrodite wrasse Thalassoma duperrey at different stages in the sex change process. Steroidogenic cells were class...
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Sexual dimorphism is a term describing morphological differences between the sexes, but is often extended to include all differences observed between females and males. Sex differentiation in vertebrates is by definition sexually dimorphic and starts at the level of the sex chromosomes. In this review the sexual dimorphism of gonadal differentiation is discussed, with a focus on human developme...
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The role of the clinical laboratory in the diagnosis of abnormalities in gonadal development is reviewed, beginning with a description of the normal differentiation of the ovary and testis and the major types of disorders encountered. The conditions are classified as resulting from abnormal gonadal differentiation, defective endocrine function or excessive endocrine activity. Germ cell neoplasm...
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Arguably the most defining moment in our lives is fertilization, the point at which we inherit either an X or a Y chromosome from our father. The profoundly different journeys of male and female life are thus decided by a genetic coin toss. These differences begin to unfold during fetal development, when the Y-chromosomal Sry ("sex-determining region Y") gene is activated in males and acts as a...
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BACKGROUND Inhibin is a tumor-suppressor and activin antagonist. Inhibin-deficient mice develop gonadal tumors and a cachexia wasting syndrome due to enhanced activin signaling. Because activins signal through SMAD2 and SMAD3 in vitro and loss of SMAD3 attenuates ovarian tumor development in inhibin-deficient females, we sought to determine the role of SMAD2 in the development of ovarian tumors...
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ژورنال
عنوان ژورنال: Reproduction
سال: 1987
ISSN: 1470-1626,1741-7899
DOI: 10.1530/jrf.0.0810295